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Current Trends in Immunology   Volumes    Volume 18 
Signaling via FcεRI stimulates human immature dendritic cells to induce Th1 differentiation via IL-12: Novel evidence of a feedback loop of allergic responses mediated by dendritic cells
Atsushi Itano, Masaaki Kawano, Rie Takagi, Kenichi Tokuyama, Sho Matsushita
Pages: 57 - 65
Number of pages: 9
Current Trends in Immunology
Volume 18 

Copyright © 2017 Research Trends. All rights reserved

The high-affinity Fc receptor molecules for IgE (FcεRI) are mainly expressed in mast cells and basophils, leading to hypersensitivity reactions. Previous studies have shown that human dendritic cells (DCs) in the peripheral blood express FcεRI on their surface, yet the specific role of FcεRI has not been clarified. We obtained immature monocyte-derived DCs (iDCs) from human peripheral blood and confirmed the expression of FcεRI. To reveal the function of FcεRI on iDCs, we specifically crosslinked FcεRI, and showed the production of interleukin (IL)-6 and tumor necrosis factor alpha (TNFα). We then co-cultured FcεRI-stimulated DCs with human leukocyte antigen - antigen D related (HLA-DR) non-shared allogeneic CD4+ naïve T cells, and showed that they led to the differentiation of naïve T cells toward the T helper 1 subset. This differentiation was inhibited by anti-IL-12 antibodies, and FcεRI-stimulated DCs enhanced the production of IL-12 upon antigen presentation. This should be a novel evidence of a negative feedback loop of allergic IgE responses via FcεRI on DCs.
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