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Current Topics in Biochemical Research   Volumes    Volume 18 
Green tea catechin, (-)-Epigallocatechin-3-gallate, suppresses TLR2-induced bone resorption by inhibiting prostaglandin E production in osteoblasts
Maki Aizawa, Tsukasa Tominari, Kenta Watanabe, Michiko Hirata, Chiho Matsumoto, Chisato Miyaura, Masaki Inada
Pages: 27 - 32
Number of pages: 6
Current Topics in Biochemical Research
Volume 18 

Copyright © 2017 Research Trends. All rights reserved

Green tea catechin is known to exhibit various biological functions, and (-)-Epigallocatechin-3-gallate (EGCG) is an active form of a family of various catechins. We examined the effects of EGCG on inflammatory bone resorption, and found that EGCG suppressed the osteoclast formation induced by the toll-like receptor 2 heterodimer, TLR2/6 and TLR2/1 ligands, in co-cultures of mouse bone marrow cells and osteoblasts. Production of prostaglandin E2 (PGE2) by osteoblasts is critical for bone resorption associated with inflammation. EGCG acted on osteoblasts and suppressed TLR2/6- and TLR2/1-dependent PGE2 production and NFκB activation. In mouse calvarial organ cultures, EGCG attenuated the osteoclastic bone resorption elicited by TLR2 heterodimer signaling. Therefore, EGCG might protect against inflammatory bone loss.
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