Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Biochemical Research   Volumes    Volume 18 
Abstract
Green tea catechin, (-)-Epigallocatechin-3-gallate, suppresses TLR2-induced bone resorption by inhibiting prostaglandin E production in osteoblasts
Maki Aizawa, Tsukasa Tominari, Kenta Watanabe, Michiko Hirata, Chiho Matsumoto, Chisato Miyaura, Masaki Inada
Pages: 27 - 32
Number of pages: 6
Current Topics in Biochemical Research
Volume 18 

Copyright © 2017 Research Trends. All rights reserved

ABSTRACT
 
Green tea catechin is known to exhibit various biological functions, and (-)-Epigallocatechin-3-gallate (EGCG) is an active form of a family of various catechins. We examined the effects of EGCG on inflammatory bone resorption, and found that EGCG suppressed the osteoclast formation induced by the toll-like receptor 2 heterodimer, TLR2/6 and TLR2/1 ligands, in co-cultures of mouse bone marrow cells and osteoblasts. Production of prostaglandin E2 (PGE2) by osteoblasts is critical for bone resorption associated with inflammation. EGCG acted on osteoblasts and suppressed TLR2/6- and TLR2/1-dependent PGE2 production and NFκB activation. In mouse calvarial organ cultures, EGCG attenuated the osteoclastic bone resorption elicited by TLR2 heterodimer signaling. Therefore, EGCG might protect against inflammatory bone loss.
Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms