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Current Trends in Immunology   Volumes    Volume 19 
Gene polymorphisms of interferons and their receptors in chronic hepatitis B virus infection and hepatocellular carcinoma
Thammakorn Saethang, Ingorn Kimkong
Pages: 41 - 49
Number of pages: 9
Current Trends in Immunology
Volume 19 

Copyright © 2018 Research Trends. All rights reserved

Chronic hepatitis B (CHB) is a serious disease caused by the hepatitis B virus (HBV). CHB can lead to liver cirrhosis and hepatocellular carcinoma (HCC). Strong evidence for the effect of host genetics has been previously reported. Hence, the difference in host genetics might affect the various outcomes of HBV infection. Polymorphisms in genes encoding interferons (IFNs) and interferon receptors such as IFN-α, IFN-γ, IFN-λ, IFNAR1, IFNAR2, IL10R2/IL10RB, IFNGR1, and IFNGR2 have been reported to be responsible for susceptibility to CHB infection. In this review, the current information in the literature on the association between gene polymorphisms of IFNs and their receptors and chronic HBV infection is summarized. This information can be used to determine the risk for CHB infection and/or the development of liver cancer. In addition, the knowledge about genetic polymorphisms could be applied for prevention, treatment of HBV infections, and the development of new therapeutics for HBV patients.
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