Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Trends in Immunology   Volumes    Volume 19 
Plasma levels of interleukin-17 and transforming growth factor-beta in vitiligo patients
Ehab M. Fahmy, Mostafa Adam Eltaieb, Mohamed M. Amin, Alzahraa Gamal, Asmaa Osman, Ahmed Abdelsadik
Pages: 77 - 81
Number of pages: 5
Current Trends in Immunology
Volume 19 

Copyright © 2018 Research Trends. All rights reserved

Vitiligo is a common dynamic depigmentary skin disorder. Several hypotheses have been proposed to explain its underlying pathogenesis, including the autoimmune hypothesis. The objectives of the current study are to assess the plasma levels of interleukin-17 (IL-17) and transforming growth factor-beta (TGF-β) in vitiligo patients. Furthermore, we aim to estimate the relationship between the severity of vitiligo, gender and age. We assessed the levels of target cytokines in fifty vitiligo patients (VG) and twenty matched healthy controls (CG). Our data showed that the mean level of IL-17 was significantly higher in VG than in CG (P = 0.004), while TGF-β values were significantly lower in VG than in CG (P = 0.002). This modulation in the level of cytokines correlated with age and degree of disease severity but not with the sex of the patients. In conclusion the study revealed the inter-opposing action of IL-17 and TGF-β in the pathogenesis of vitiligo, as well as verified that no correlation exists between disease severity and the sex of the patient.
View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms