Increased consumption of deep-fried and baked food items has escalated acrylamide exposure in humans, eliciting a myriad of toxic clinical effects. Acrylamide (ACR)-triggered reproductive toxicity is widely studied in animal models, with little information available on its impact on humans. Clinical manifestations associated with acrylamide toxicity include decreased body weight, lowered testosterone levels, and testicular impairment, as confirmed by its histopathological evaluation. Several molecules belonging to the domain of nutraceuticals or metabolites are found to mitigate this acrylamide-induced testicular toxicity by virtue of their antioxidant property. The current review discusses the underlying mechanisms of acrylamide intoxication in the male reproductive system and provides a comprehensive knowledge of the mitigation strategies associated with the reported issue.