The purpose of the study is to find out the impacts of glutathione on vital parameters and oxidative stress in goats exposed to lead acetate toxicity. Twenty goats were assigned into five herds of four animals each. The herds received the following treatments: Control group was administered with distilled water; lead (10 mg/kg); lead (10 mg/kg)+glutathione (50 mg/kg); lead (10 mg/kg)+glutathione (100 mg/kg) and lead (10 mg/kg)+glutathione (200 mg/kg). The animals received the treatments daily through the oral route for 21 days. The rectal temperatures, respiratory and heart rates of the goats were monitored daily and recorded. Malondialdehyde, superoxide dismutase and catalase levels were estimated in the serum, lungs, livers and kidneys. Significant reductions (p<0.05) were recorded in the rectal temperatures of the bucks in the lead (10 mg/kg) and lead (10 mg/kg)+glutathione (200 mg/kg) groups on day 21 compared to day 0. Also, lead elicited increments (P<0.05) in the malondialdehyde concentrations in the lungs, livers and kidneys of the goats, and brought about declines (P<0.05) in the levels of catalase in the serum, lungs and kidneys of the animals. The malondialdehyde concentrations were reduced (P<0.05) in the livers and kidneys of the glutathione groups. The activities of catalase were boosted (P<0.05) in the serum, lungs and kidneys of the bucks that received glutathione. It was surmised that glutathione could be useful in counteracting lead-provoked oxidative stress in goats.