Chemical composition and biological activities of genus Psoralea has been revised. Monoterpenoids, meroterpenoids, triterpenoids, alcaloids, phenols, chalcones, coumestrols, coumarins, flavonoids, quinones and other related compounds, has been isolated as mainly compounds of this genus. Antimutagenic, antimicrobial, antiviral, antipiretic, analgesic, and other biological activities have been reported for compounds from genus Psoralea.