Prototype fibroblast growth factors (FGFs) such as FGF-1 and -2 are classical, but potent angiogenesis stimulators. Blood vessel endothelial cells are the targets of angiogenic stimuli. FGFs mediate their actions through FGF receptor (FGFR) tyrosine kinases. FGFR tyrosine kinase activates a number of downstream signaling cascades. In this review, we discuss the role of each of these pathways in poliferation, migration, protease production, and tube formation (i.e. differentiation) of endothelial cells.