ABSTRACT In this review we showed that experimental brain ischemia-reperfusion episode produces neurochemical and neuropathological changes that simulate early stage of Alzheimer’s disease process. Presented data suggest that ischemic mechanisms of neuronal death with ß-amyloid peptide from circulatory network modulate neuropathology of cerebral ischemia-reperfusion injury via molecular events in common with Alzheimer-type neuropathology. These results indicate that ischemic brain processes might be a key factor in the development the picture of Alzheimer-type dementia over years. The collective data summarized in this paper strongly support the idea that sporadic form of Alzheimer’s disease is a neurovascular disorder.
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