Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Biochemical Research   Volumes    Volume 20 
Abstract
Atherosclerosis experimental model and the effects of extra virgin olive oil on the heart and peripheral arteries of rats
Géssica de Mattos Diosti, Fernanda Christo Lovato, Nabil Musa, Kárita Cláudia Freitas Lidani, Luiz Martins Collaço, Camila Moraes Marques, Luiz Fernando Kubrusly
Pages: 33 - 41
Number of pages: 9
Current Topics in Biochemical Research
Volume 20 

Copyright © 2019 Research Trends. All rights reserved

ABSTRACT
 
Atherosclerosis is a multifactorial disease resulting from the development and progression of atheromatous plaque. Thus, the nature and amount of lipids in the diet may act as a risk or protective factor for cardiovascular impairment. The extra virgin olive oil, due to its antioxidant power, was used in this study to evaluate its therapeutic effects on the atherosclerosis process. Male Wistar rats were divided into 6 groups: negative control, normocaloric diet and olive oil, positive control, high fat diet and olive oil, high fat diet and olive oil with fasting and dyslipidemia induction group with high fat diet/treatment with olive oil. After 90 days, blood was collected. Euthanasia was performed and carotid arteries, abdominal aorta and iliac vessels were removed for histopathological analysis. Areas of vacuolar degeneration and pyknotic nuclei were not found. Aorta histological analysis showed grade II lesions in all animals that consumed olive oil as treatment after induction of dyslipidemia, whereas only 20% of the animals in the group in which normocaloric diet and olive oil were administered throughout the experiment presented the same lesion degree (intimal thickening and presence of foam cells). The triglycerides/HDL index was significantly lower in the normocaloric diet group than in the dyslipidemia and subsequent ingestion of olive oil group (p = 0.0159). The continuous administration of a balanced diet and extra virgin olive oil has a potential positive effect on the lipid profile and subsequent formation of atheroma plaque.
View Full Article  


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms