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Current Topics in Biochemical Research   Volumes    Volume 21 
A review on the role of cobra snake venom composition in oxidative stress and inflammation
Asmaa Saad Mahmoud Shokhba, Mohammed Alaa El-Deen A. Omran, Mohamed A. Abdel-Rahman, Nahla Soliman El-Shenawy
Pages: 99 - 118
Number of pages: 20
Current Topics in Biochemical Research
Volume 21 

Copyright © 2020 Research Trends. All rights reserved

Cobra venom is composed of various proteins, peptides, and enzymes with different biological and pharmacological functions. Several previous studies have reported that Naja venom exerts potent analgesic effects on various animal models of pain. The clinical studies using whole venom or active components have confirmed that Naja venom is an effective and safe medicine for the treatment of chronic pain. Furthermore, recent studies have demonstrated that it has immune regulatory and anti-inflammatory actions in vivo and in vitro. In this review article, we summarize recent studies on the role of Naja venom and its components in inflammation, oxidative stress, and immunity. The main new findings in Naja venom research show that it may enhance innate and humoral immune responses while suppressing T lymphocyte-mediated cellular immunity (several cellular-immune reactions), thus suggesting that Naja active components may have therapeutic values in the treatment of inflammatory and autoimmune diseases.
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