In the present study, the solubility behavior of amlodipine besylate (ADB) in the binary mixtures of ethylene glycol + 1-propanol at five different temperatures (293.2-313.2 K) was investigated. The experimental data obtained from the shake-flask method was correlated with some of the reported cosolvency models (i.e. the van’t Hoff, CNIBS/Redlich–Kister, the Jouyban-Acree, the Jouyban-Acree-van’t Hoff, the mixture response surface (MRS), modified Wilson, and Buchowski–Ksiazczak models). The accuracy of these models was investigated using the mean relative deviations of the back-calculated solubility data. The apparent thermodynamic parameters (Gibbs energy, enthalpy and entropy) of ADB in the investigated non-aqueous saturated mixtures were also calculated using the van’t Hoff and Gibbs equations at T_hm.