Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Trends in Immunology   Volumes    Volume 22 
Tannic acid, a dopamine receptor agonist, ameliorates periodontitis, atopic dermatitis and psoriasis in animal models
Rie Takagi, Masaaki Kawano, Tsuyoshi Sato, Sho Matsushita
Pages: 11 - 17
Number of pages: 7
Current Trends in Immunology
Volume 22 

Copyright © 2021 Research Trends. All rights reserved

Signaling via dopamine receptors affect IL-17 secretion from Th17 cells, as shown in our previous studies. Tannic acid (TA) is a herbal polyphenol containing a galloyl group with anti-inflammatory and anti-viral properties. In our recent previous study, we found that i) TA is an agonist of the dopamine D2L receptor (D2LR); ii) TA enhances IL-10 secretion from lipopolysaccharide (LPS)-stimulated mouse splenocytes; iii) TA also enhances IL-10 but reduces IL-17 secretion from anti-CD3/CD28 antibody-stimulated splenocytes. In addition, iv) administration of TA to mice with experimentally induced neutrophilic colitis strikingly suppresses weight loss, colon shrinkage, and IL-17 secretion from mesenteric lymph node lymphocytes. Because IL-17 is one of the essential cytokines to induce neutrophilic inflammation, we in this study tested the effect of TA on other neutrophilic inflammation models in rodents, such as carrageenan-induced periodontitis, 2,4,6-trinitrochlorobenzene-induced atopic dermatitis, and imiquimod-induced psoriasis. We successfully showed that i) TA is effective in reducing the resorption of the alveolar bone in periodontitis model and in atopic dermatitis model; ii) TA and gallic acid are effective in easing psoriasis model as well as neutrophilic inflammation; and iii) not only TA but also related compounds such as gallic acid, epicatechin gallate, and epigallocatechin gallate are D2LR agonists. Therefore, TA and related compounds are effective in in vivo animal models for neutrophilic inflammation.
View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms