Diabetes mellitus type 1 is an inflammatory disease caused by an autoimmune response. It is known that its pathogenesis involves a dysfunction in the major histocompatibity complex associated with environment factors, in genetically susceptible people. The destruction of β cells is mediated by T and B cells, NK cells and APCs infiltration in the islets of Langerhans, leading to low production of insulin and high glucose blood levels. On the other hand, helminth infections are described as modulators of inflammatory responses due to their capacity to strongly induce Th2 and Treg immune responses. Some studies on autoimmunity diseases, in experimental models and clinical trials, have shown an immune modulation by helminths infections. In this study, we investigated whether Necator americanus crude extract interferes in autoimmune experimental diabetes.