Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Trends in Immunology   Volumes    Volume 22 
Crude Necator americanus worm extract diminishes pancreatic islet destruction in diabetic non-obese mice (NOD)
Teresiama Velikkakam, Bruna Gazedim, Érica Alessandra Rocha Alves, Ricardo Toshio Fujiwara, Lilian Lacerda Bueno, Jacqueline Araújo Fiuza, Soraya Gaze
Pages: 55 - 67
Number of pages: 13
Current Trends in Immunology
Volume 22 

Copyright © 2021 Research Trends. All rights reserved

Diabetes mellitus type 1 is an inflammatory disease caused by an autoimmune response. It is known that its pathogenesis involves a dysfunction in the major histocompatibity complex associated with environment factors, in genetically susceptible people. The destruction of β cells is mediated by T and B cells, NK cells and APCs infiltration in the islets of Langerhans, leading to low production of insulin and high glucose blood levels. On the other hand, helminth infections are described as modulators of inflammatory responses due to their capacity to strongly induce Th2 and Treg immune responses. Some studies on autoimmunity diseases, in experimental models and clinical trials, have shown an immune modulation by helminths infections. In this study, we investigated whether Necator americanus crude extract interferes in autoimmune experimental diabetes.
View Full Article  


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms