Studies show that some people are living with undiagnosed pre-diabetes while also carrying the human immunodeficiency virus (HIV). Pre-diabetes is a state of intermediate hyperglycaemia that often precedes the onset of type 2 diabetes. HIV has been reported to affect the immune system as well as the secretion of cytokines involved in the inflammatory response. At this stage it is still a debatable issue if all the abnormalities observed in type 2 diabetes develop during pre-diabetes. However, the coexistence of diabetes and HIV can exacerbate chronic inflammation and could further compromise the immune system. Reports have shown that the long noncoding RNAs are expressed by various immune cells upon immune activation. This then gave rise to the idea of using long noncoding RNAs as therapeutic agents to improve the immune system. Therefore, this review sought to explore if long noncoding RNAs could be a possible solution to the increased inflammation at a genetic level during pre-diabetes in HIV-positive patients.