Peripheral compressive neuropathies (PCNs) include several chronic syndromes, such as cervicobrachialgia, lumbalgia, lumbosciatalgia and carpal tunnel syndrome. All of these conditions are characterised by pain and sensorial symptoms, which include analgesia, paraesthesia and allodynia. In the absence of a surgical indication or in case of delayed intervention, the conservative treatment is based on both analgesic and anti-inflammatory drugs, with potential risks of side effects, particularly in elderly, and physical therapy. Thus, the search for effective and safe substances represents an unmet medical need. In this review, we examine the rationale for the development of a new multicomponent nutraceutical and its potential use in the treatment of PCNs. A multicomponent nutraceutical that contains acetyl-L-carnitine (ALC), palmitoylethanolamide (PEA), Boswellia serrata (BS), vitamin B6 and vitamin E has been recently developed (Kalanit®, Chiesi Farmaceutici S.p.A., Italy). We examine the possible mechanism of action of all components and the available clinical evidence in their clinical use in peripheral neuropathies. As a result of our search, it can be postulated that the new multicomponent nutracetical may be an effective and well tolerated supplement in the management of PCNs, either as a single agent or in combination with conventional pharmacological and/or physical therapies.
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