Plants contain many anti-amyloidogenic molecules that can play a significant role in the prevention of currently incurable neurodegenerative diseases. Our experiments proved that quercetin and choline bitartrate are anti-amyloidogenic agents in vitro, as they effectively inhibit the formation of α-chymotrypsin amyloid fibrils at pH 7.0 in 55% ethanol. The effect of quercetin and choline bitartrate on protein aggregation and fibril formation was concentration-dependent based on turbidity measurements and Congo red binding assays.