The inhibitory properties of clotrimazole, metronidazole, and ibuprofen against biofilms of both bacteria and fungi were studied. The distinct antibiofilm effect of a potential combined drug MCI-4 against Staphylococcus aureus, yeast-like fungi, and microbial associations formed by Staphylococcus aureus 222 and Candida albicans 1486 was experimentally proven.