Platinum compounds (cisplatin, carboplatin, and oxaliplatin) are a category of chemotherapeutics widely used in the therapy of various cancers because of their high efficacy and tolerability. Cases of hypersensitivity reactions to these compounds have increased in recent decades due to their frequent use. Carboplatin is the platinum compound associated with the highest incidence of immediate hypersensitivity reactions. It is critical for clinicians to be familiar with allergy diagnostics and to correctly diagnose immediate hypersensitivity reactions to platinum compounds and to identify sensitized patients to both reduce the risk of severe reactions and to continue effective chemotherapy treatment.