The present study aimed to utilize all the benefits of silver, chitosan, and ascorbic acid -in the form of nanoparticles- such as wound healing, antioxidant, antibacterial, and anti-inflammatory properties in treating gastric ulcers. Thirty rats were assigned into five groups. Gastric ulcer was induced by 99% ethanol (5 ml/kg body weight; orally). One hour later, the ulcerated rats were administrated distilled water (Ulcer group), 0.25 mg/Kg of silver-chitosan-ascorbic acid nanocomposites (NC group), 50 mg/Kg of ranitidine (Ran. group), and NCs + ranitidine (NC + Ran. group). NCs and or ranitidine caused a significant decrease in ulcer index, gastric juice volume, and malondialdehyde, while gastric juice pH, glutathione, and catalase increased significantly in addition to the significant histological improvement of the gastric mucosa. Silver-chitosan-ascorbic acid nanocomposites are a promising treatment modality against gastric injury through their powerful antioxidant, acid neutralizing, and healing promotion effects.