The COVID-19 pandemic has impacted not only our physical health, but also our mental well-being, leaving long-lasting scars that time might heal. Antidepressants are known to alleviate stress, anxiety, and depression by modulating specific neurotransmitters that are associated with these conditions, which aid in communication between brain cells, and each antidepressant acts on these neurotransmitters in slightly different ways, making them a popular treatment choice. We describe in this prospective longitudinal observational study ten COVID-19-positive cases with severe disease symptoms and post-infection mental scars, who were prescribed fluoxetine and paroxetine. These treated cases experienced a progressive reduction of illness severity and anxiety upheaval surrounding this pandemic, which may involve the negative action of stress on COVID-19 patients and the positive action of antidepressants against the viral disease. Effective treatments of COVID-19, especially those that are easy to use, show good tolerability, and have widespread availability at low cost, with their less bothersome effects and non-addictive properties should be widely studied.