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Current Topics in Pharmacology   Volumes    Volume 27 
Antioxidant properties of morin against arsenic neurotoxicity in rats showed ameliorative effects on pain and inflammation
Praveen Nadipolla, Bhaskar Nagilla, Pratap Reddy Karnati
Pages: 91 - 104
Number of pages: 14
Current Topics in Pharmacology
Volume 27 

Copyright © 2023 Research Trends. All rights reserved

Experimental evidence has demonstrated that arsenic exposure, whether acute or chronic, is detrimental to all systems of the body. This study aims to investigate whether morin could decrease the neurotoxic impact of arsenic on Wistar rats concerning pain and inflammation. Arsenic (20 mg/kg body Wt.) was administered orally to Wistar rats. We kept one group of animals on drinking water, and the other group received treatment with morin (50 mg/kg body Wt.).The 28-day experiment was conducted weekly, i.e., on the 7th, 14th, 21st, and 28th day. Nociceptive pain was measured by the tail flick test (TFT) and hot plate test (HPT), while inflammatory pain was measured by Randal pain test (RPT). On the 28th day, animals were sacrificed. Catalase, superoxide dismutase activity, lipid peroxidation and glutathione (GSH) were measured in the brain tissue. Histological alterations in the cerebral cortex and hippocampus were studied using Congo red stain. Morin showed a significant antinociceptive effect as evidenced by TFT and HPT and an anti-inflammatory effect as demonstrated by RPT. Arsenic increased lipid peroxidation and inhibited the activities of superoxide dismutase, glutathione content and catalase simultaneously. The administration of morin suppressed lipid peroxidation while concurrently increasing the activities of catalase and superoxide dismutase and the glutathione content. Conversely, morin ameliorated the alterations in cerebral cortex and hippocampal histology in arsenic-poisoned rats. Consequently, morin showed antinociceptive, anti-inflammatory, and antioxidant qualities against arsenic-induced neurotoxicity in rats.
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