Experimental evidence has demonstrated that arsenic exposure, whether acute or chronic, is detrimental to all systems of the body. This study aims to investigate whether morin could decrease the neurotoxic impact of arsenic on Wistar rats concerning pain and inflammation. Arsenic (20 mg/kg body Wt.) was administered orally to Wistar rats. We kept one group of animals on drinking water, and the other group received treatment with morin (50 mg/kg body Wt.).The 28-day experiment was conducted weekly, i.e., on the 7^th, 14^th, 21^st, and 28^th day. Nociceptive pain was measured by the tail flick test (TFT) and hot plate test (HPT), while inflammatory pain was measured by Randal pain test (RPT). On the 28^th day, animals were sacrificed. Catalase, superoxide dismutase activity, lipid peroxidation and glutathione (GSH) were measured in the brain tissue. Histological alterations in the cerebral cortex and hippocampus were studied using Congo red stain. Morin showed a significant antinociceptive effect as evidenced by TFT and HPT and an anti-inflammatory effect as demonstrated by RPT. Arsenic increased lipid peroxidation and inhibited the activities of superoxide dismutase, glutathione content and catalase simultaneously. The administration of morin suppressed lipid peroxidation while concurrently increasing the activities of catalase and superoxide dismutase and the glutathione content. Conversely, morin ameliorated the alterations in cerebral cortex and hippocampal histology in arsenic-poisoned rats. Consequently, morin showed antinociceptive, anti-inflammatory, and antioxidant qualities against arsenic-induced neurotoxicity in rats.