ABSTRACT

The effect of most neuroactive substances is subsequent to their binding at specific sites of specific macromolecules, the receptors, inserted in synaptic region membranes. Interaction of classical neurotransmitters and diverse neuropeptides with their receptors at postsynaptic membranes leads to message transmission both at central and peripheral nervous system level, occurring between two neurons or between a neuron and an effector cell. Neuroactive substances also interact with presynaptic receptors, in which case they regulate neurotransmitter release. Besides, glial cell neurotransmitter receptors are target sites for such agents.

Sodium pump or its enzymatic version, Na⁺ K⁺- ATPase, is responsible for cation movement which occurs after the passage of nervous impulse and its activity is inhibited by ouabain and related cardiac glycosides.