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Current Topics in Phytochemistry   Volumes    Volume 3 
Abstract
The chemistry of pentalenolactones . An overview
Rolando A. Spanevello, Silvina C. Pellegrinet
Pages: 225 - 231
Number of pages: 7
Current Topics in Phytochemistry
Volume 3 

Copyright © 2000 Research Trends. All rights reserved

ABSTRACT

The pentalenolactones are a growing family of acidic lipophilic sesquiterpenes with a highly compacted carbon skeleton. They present an angularly fussed tricyclo pentanoid lactone with different states of oxidation in each of the three rings. These natural products have been isolated from a variety of Streptomyces species and have shown antibiotic, antiviral and antitumoral properties. Special efforts have been devoted to study the inhibition of glyceraldehyde-3-phosphate dehydrogenase by pentalenolactone in Trypanosome brucei. These important biological effects have promoted considerable synthetic research in this area.

 

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