Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Biochemical Research   Volumes    Volume 3 
Insulin and vascular function in hypertension
Subodh Verma, Aaron S. Dumont, John H. McNeill
Pages: 131 - 137
Number of pages: 7
Current Topics in Biochemical Research
Volume 3 

Copyright © 2000 Research Trends. All rights reserved


A growing body of recent evidence suggests, that insulin, in addition to its well-known effects on carbohydrate, protein and lipid metabolism, exerts important actions on endothelial function and vascular tone. This has led to the hypothesis that in states of insulin resistance/hyperinsulinemia, alterations in the vascular actions of insulin may be important in the development and/or reinforcement of hypertension. In this mini-review we discuss (1) the hemodynamic actions of insulin, (2) the direct actions of insulin on vascular tone in states of insulin resistance and hypertension, (3) the interaction of insulin and endothelin-1 and lastly (4) the effects of calcium antagonists on plasma insulin levels and blood pressure. Most of the experiments outlined were conducted in the fructose-induced hypertensive rat model wherein feeding normal Sprague-Dawley rats a 60% fructose diet results in hyperinsulinemia, insulin resistance and elevated blood pressure.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms