Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Biochemical Research   Volumes    Volume 3 
Oxidative imbalance is a major feature of Alzheimer disease
George Perry, Akihiko Nunomura, Paul K. Jones, Catherine A. Rottkamp, Xiongwei Zhu, Gjumrakch Aliev, Adam D. Cash, Mark A. Smith
Pages: 151 - 156
Number of pages: 6
Current Topics in Biochemical Research
Volume 3 

Copyright © 2000 Research Trends. All rights reserved


Oxidative damage, involving all categories of biological macromolecules, is greatly increased in Alzheimer disease. However, while there are signs of systemic alterations in oxidative balance, the significant increase in damage is restricted to the cell bodies of susceptible neurons in the disease. This localization is consistent with an abnormality in the neuronal cytoplasm. Ultrastructural analysis of the site of nucleic acid oxidation shows the damage is restricted to the endoplasmic reticulum and free ribosomes, while morphometic analysis shows that mitochondria are largely unchanged in size and number. In contrast, mitochondrial markers, such as mitochondrial DNA or cytochrome oxidase, are increased several fold suggesting that increased oxidative damage may be as much a result of decreased turnover of damaged components as it is of increased production of oxidized macromolecules. The extent of abnormalities, as well as their chronic nature, suggest that a fundamental metabolic compromise is crucial to disease development.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms