Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Biochemical Research   Volumes    Volume 3 
Abstract
Antiviral activity of lactoferrin
Nobuyuki Kato, Akito Nozaki, Atsushi Naganuma, Masanori Ikeda, Katsuaki Tanaka
Pages: 163 - 173
Number of pages: 11
Current Topics in Biochemical Research
Volume 3 

Copyright © 2000 Research Trends. All rights reserved

ABSTRACT

Lactoferrin (LF), which is a milk protein belonging to the iron transporter family, is known to be a primary defense protein against pathogenic microorganisms. Recently, several groups have reported that human and/or bovine LF has inhibitory activity against pathogenic viruses including human herpes simplex virus-1, human cytomegalovirus, human immunodeficiency virus-1 and simian rotavirus, although the inhibitory mechanisms have not been clarified. Recently, we also found that both human and bovine LFs effectively and specifically prevented hepatitis C virus (HCV) infection in cultured human hepatocytes, which were susceptible to HCV infection and supported HCV replication. The HCV inhibitory activity of LF was found to be due to a direct interaction between LF and HCV. In addition, infection with hepatitis G virus, which is distantly related to HCV, was also prevented by LF. Further in vitro analysis using recombinant proteins demonstrated a direct interaction between LF and HCV E2 envelope protein, and identified the binding regions of LF. In clinical trials of LF in patients with chronic hepatitis C, some patients receiving LF showed improvement of hepatitis and a decrease in serum HCV RNA levels. The possible application of LF for further clinical therapy is discussed.

Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms