The diaphanous related-formins (DRFs) are members of the formin family of proteins defined by shared formin homology (FH) domains FH1 and FH2 as well as Rho GTPase binding sites and autoinhibitory regulation domains. They act as effectors of Rho GTPase activity and are responsible for nucleation of unbranched actin polymerization and microtubule stabilization. These functions place them in control of diverse and critical processes including controlling cell morphology, motility, attachment, division, and polarization. Recent studies reveal that they are also involved in endosomal trafficking, contractile ring positioning and filiopodia formation. In this review we summarize emerging functions of the DRF family of proteins.
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