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Trends in Developmental Biology   Volumes    Volume 3 
Astrocytic bone morphogenetic Astrocytic bone morphogenetic protein signaling modulates the functional blood-brain-barrier
Masahisa Yamada, Haruo Kishida, Naohito Kitamura
Pages: 19 - 23
Number of pages: 5
Trends in Developmental Biology
Volume 3 

Copyright © 2008 Research Trends. All rights reserved

Angiogenesis is a multistep process that involves  proliferation and migration of endothelial cells (ECs) and generation of extracellular matrix. Angiogenesis is regulated by multiple positive-  and negative-regulatory factors. Astrocytes,  whose  endfeet encircle neural capillaries, produce angiogenesis-modulating factors, and together with ECs, play a key role in forming and maintaining the blood-brain-barrier (BBB). It has been suggested  that closure of the BBB is correlated to  maturation of astrocytes. Recently we found that bone morphogenetic protein type I receptor (BMPRIA) in astrocytes played a critical role in interactions between ECs and astrocytes to form a functional BBB. Here we review the latest  advances in our understanding of the astrocytic bone morphogenetic protein (BMP) signaling mechanism of action and its in vivo functions.
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