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Trends in Cancer Research   Volumes    Volume 3 
Lessons from ovarian cancer patients with more than 10 years survival
Masashi Takano, Kazuya Kudoh, Tsunekazu Kita, Kenichi Furuya, Yoshihiro Kikuchi
Pages: 39 - 45
Number of pages: 7
Trends in Cancer Research
Volume 3 

Copyright © 2007 Research Trends. All rights reserved

Purpose of this retrospective study is to explore predictive factors for long-term survival in patients with primary epithelial ovarian carcinoma. Total 161 patients treated from March 1983 to December 1994 at the National Defense Medical College hospital were enrolled in this study. Profiles and characteristics of patients with long term survival were retrospectively examined. All patients with stage Ia, b or IIa, b survived more than 10 years although 2 of patients with stage Ia or b tumor were dead of primary disease and one patient was dead of other disease after more than 10 years follow-up. More than half of patients with stage Ic, IIc or IIIa, b survived more than 10 years, while 10-years’ survival rates of patients with stage IIIc or IV were only 10% with marked increase of death by primary disease. All patients with stage I or IIa, b without residual tumor after initial surgery survived more than 10 years. Although long-term survival rates of patients with stage IIc or IIIa, b were higher in patients without residual timor after initial surgery, 6 out of 7 patients with stage IIIc or IV had residual tumor. Analyses of 70 patients with stage III or IV ovarian cancer revealed that residual tumor size, histologic types and response to initial chemotherapy affected significantly long-term survival. We demonstrated that predictors for long-term survival were stage, residual tumor size after initial surgery, histology, response to initial chemotherapy.
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