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Current Trends in Medicinal Chemistry   Volumes    Volume 3 
Abstract
The renascence of fibrates in the management of dyslipidemia: from myopathy to activation of peroxisome proliferator-activated receptors (PPARs)
Vincenzo Tortorella, Fulvio Loiodice
Pages: 187 - 201
Number of pages: 15
Current Trends in Medicinal Chemistry
Volume 3 

Copyright © 2003 Research Trends. All rights reserved

ABSTRACT

Fibrates, a well-known class of lipid-lowering drugs, have been shown to induce myopathy through different mechanisms among which one of the most important is the influence on the chloride conductance of the skeletal muscle fibers. Electrophysiological studies, in fact, showed a concentration-dependent inhibition of the chloride ion flux of the muscle membrane which, for some chiral analogs, is strictly dependent on the absolute configuration. In recent years, however, fibrates have gained new interest due to the discovery of their ability to act as ligands for the peroxisome proliferator-activated receptors (PPARs), trascription factors involved in control of lipid and carbohydrate metabolism, and to the ensuing possible use for the treatment of Type 2 diabetes mellitus.

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