Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
ID:
Password:
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

Agents/Distributors
 Regional Subscription Agents/Distributors
 
Current Topics in Neurochemistry   Volumes    Volume 4 
Abstract
Transcription factors as novel antidepressant drug targets-with special regard to transcription factor AP-2
Mattias Damberg
Pages: 71 - 74
Number of pages: 4
Current Topics in Neurochemistry
Volume 4 

Copyright © 2005 Research Trends. All rights reserved

ABSTRACT

The recently gained knowledge in molecular pharmacology has raised interesting ideas to drug design. The progress in understanding transcription factor structure, function and regulation has opened up new strategies for direct and selective pharmacological enhancement or lowering of the expression of a gene by rational targeting of specific transcription factors. In the central nervous system, transcription factor AP-2 family is one of the critical regulatory factors for neural gene expression and neuronal development. A number of genes in the monoaminergic systems, suggested to be involved in psychiatric disorders, have AP-2 binding sites in regulatory regions and several studies have indicated that transcription factor AP-2 is involved in the monoaminergic systems. Transcription factor AP-2β genotype has been studied in relation to personality, platelet monoamine oxidase (MAO) activity, CSF-levels of monoamine metabolites, binge-eating disorder, premenstrual dysphoric disorder, and schizophrenia. In this paper, the involvement of transcription factor AP-2 in monoaminergic functions is discussed. We have also made an effort to elucidate the effect of antidepressant treatment on transcription factor AP-2.

Buy this Article


 
search


E-Commerce
Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Login
Search Products
Browse in Alphabetical Order : Journals
Series/Books
Browse by Subject Classification : Journals
Series/Books

Miscellaneous
Ordering Information Ordering Information
Downloadable forms Downloadable Forms