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Current Topics in Virology   Volumes    Volume 4 
Abstract
The role of cholesterol rich domains and cellular proteins in mouse retrovirus assembly
Christiane Beer, Manfred Wirth
Pages: 169 - 183
Number of pages: 15
Current Topics in Virology
Volume 4 

Copyright © 2004 Research Trends. All rights reserved

 ABSTRACT

Cholesterol rich domains have been identified as regions of the membrane which  play an important role in the entry, assembly and release of several viruses e.g. HIV-1, the ecotropic  Moloney murine leukaemia virus and measles virus. We will summarize recent results on the assembly of murine retroviruses (ecotropic and amphotropic) and lentivirus HIV-1. For assembly viral components are concentrated in lipid rafts as well as foreign proteins and both are incorporated into the budding virus. We will focus on the factors determining transport to and association with lipid rafts and discuss the role of caveolin, the defining protein of cellular invaginations termed caveolae, which has been found to be incorporated into amphotropic 4070 A viruses.

 

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