In association with pathogen, plants have evolved sophisticated defense mechanisms to perceive pathogen attack and to translate that perception into defensive responses, which is presumably applied for developing universal strategies to manage plant disease. The studies in biodegradation as protection against microbial infection have been intensified in recent years. Some oligosaccharides, such as chitooligosaccharide, oligogalacturonides, xyloglucan-derived oligosaccharide, xylooligo-saccharide, xanthooligosaccharide and oligo-guluronate, have been demonstrated to act as elicitors inducing defense responses helping  plant resist pathogen infection. Most of those oligosaccharides are enzymatically degraded from the plant or pathogen cell wall as well as carbohydrate-based virulence factor. The concentration of autoinducers is a key factor in triggering virulence gene expression in quorum-sensing pathogen. Its degradation possibly is applied in developing a strategy for disease control. In this paper the biodegradation used for protection against plant diseases was elucidated, including polysaccharides sourced from the cell wall or exopolysaccharides of pathogen, as well as quorum sensing signals or virulence factors from pathogenic microorganisms.