Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Toxicology   Volumes    Volume 4 
Ferritin role in iron toxicity in animals and plants
Andrea Galatro, Ivan Rousseau, Susana Puntarulo
Pages: 65 - 76
Number of pages: 12
Current Topics in Toxicology
Volume 4 

Copyright © 2007 Research Trends. All rights reserved

The amount of iron within the cell is carefully regulated in order to provide an adequate level of micronutrient while preventing its accumulation and toxicity. Iron excess is believed to generate oxidative stress, understood as an increase in the steady state concentration of oxygen radical intermediates. Iron is transported and stored in specific proteins (transferrin, lactoferrin, ferritin and heme proteins). Excess iron is sequestered in ferritin, the main intracellular iron storage protein. Ferritins play a key role in preventing iron toxicity because of their ability to sequester several thousand iron atoms in their central cavity in a soluble, non-toxic bioavailable form. However, there are indications that ferritins may have other functions in addition to the well assessed role in storing intracellular iron. Moreover in plants, since in the presence of oxygen, iron solubility and iron toxicity through free radical production are major problems, iron traffic has to be strictly controlled and ferritin is one of the proteins involved. The understanding of the biological functions of the iron storage compartment is a major challenge which is relevant not only to normal physiology but also to understand many diseases associated with perturbations of iron metabolism and their treatment. In this context, it is feasible to consider ferritin form plants as a novel alternative dietary iron source with an enormous potential contribution to the eradication of global iron deficiency.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms