Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Cancer Research   Volumes    Volume 4 
The role of cyclin E in normal and cancer cell cycles
Nikki A. Delk, Khandan Keyomarsi
Pages: 25 - 41
Number of pages: 17
Trends in Cancer Research
Volume 4 

Copyright © 2008 Research Trends. All rights reserved

Cyclin E is an important cell cycle regulator and oncoprotein. In normal cells cyclin E promotes G1 to S phase transition, endoreduplication, histone biosynthesis, and DNA and centrosome replication. Cyclin E function is mitigated through interaction with the cyclin dependent kinase, Cdk2. However, cyclin E and Cdk2 knockout mice reveal Cdk2-independent functions of cyclin E such as G0 release and cell transformation. Understanding the function of cyclin E in normal cell division provides insight into the mechanisms of cyclin E-mediated tumorigenesis. In particular, deregulation of cyclin E can accelerate G1 phase, prolong S phase, and impair mitotic progression thereby abrogating proper cell division and inducing genomic instability. Cyclin E deregulation, including gene amplification, protein overaccumulation, and the generation of low molecular weight cyclin E isoforms is observed in many tumor types and may contribute to tumor pathology. Defining the regulation and function of cyclin E can help researchers better understand cancer biology and design effective cancer treatment strategies. In this review we outline the role of cyclin E in normal cells and the consequences of cyclin E deregulation in cancer.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms