Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Trends in Immunology   Volumes    Volume 5 
Disparate mechanisms drive antibody diversity among mammals: A useful addition to immunology textbooks
J. E. Butler
Pages: 1 - 18
Number of pages: 18
Current Trends in Immunology
Volume 5 

Copyright © 2003 Research Trends. All rights reserved


Since 1970, immunological research evolved from a polyspecies to a monospecies science, the latter based on laboratory strains of Mus musculus. The successful evolutionary rise of the laboratory mouse parallels the relative extinction of research on other mammals to the extent that textbook concepts are based almost entirely on studies in mice and humans.

This mini-review examines the validity of this monospecies approach by reviewing a single immunological concept; mammalian B cell and antibody repertoire development.  While the genomic organization of loci, the conserved structure and genetics of Igs like IgM and IgE and the retention of many similar lymphoid tissues appear universal, others are liberally diverse. These include the: (a) mechanisms used in developing the B-cell repertoire, (b) diversification of IgG into subclasses, (c) expression and structure of IgD, (d) role of the thymus in B-cell development, (e) functional and structural diversity of hind gut lymphoid tissues and (f) use of light chains. Since many of these differences/similarities among mammals are inconsistent with phylogeny, they suggest that regulation my be more important than genetic organization and constitution. While the mouse model has made extraordinary contributions to immunology, caution is needed in applying the concepts and paradigms developed from studies in mice to all mammals. The safest “model” is always the species that you want to study. This review therefore asks the broader questions of whether the “models” chosen for immunological research generate global concept(s) or species-specific concepts?

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms