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Current Trends in Immunology   Volumes    Volume 5 
The spleen during human severe hepatosplenic schistosomiasis
Andréa Teixeira Carvalho, Zilton A. Andrade, José Renan Cunha Melo, Rodrigo Corrêa Oliveira, Olindo Assis Martins Filho
Pages: 73 - 80
Number of pages: 8
Current Trends in Immunology
Volume 5 

Copyright © 2003 Research Trends. All rights reserved


The spleen is an important immunologically active compartment, where cells from the immune system interact with parasite-derived antigens during Schistosoma mansoni infection. Morphometric and structural changes in the spleen as well as alteration on its cellularity during chronic infection might be associated with the clinical findings on the hepatosplenic disease. Some morphologic aspects of the splenomegaly, profile of cell phenotype during severe chronic infection, dynamic aspects of possible explanations of the hepatosplenic disease development are discussed. This review will attempt to summarize these findings during human chronic schistosomiasis and discuss how they may contribute to the clinical manifestations observed in the hepatosplenic disease.

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