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Current Trends in Neurology   Volumes    Volume 5 
Abstract
Effects of a β2 adrenergic receptor agonist on the ontogeny of chick nervous system
Guadalupe García-Alcocer, Patricia Nieto Leal, Laura Cristina Berumen, Angelina Rodríguez Torres, Ricardo Miledi
Pages: 45 - 48
Number of pages: 4
Current Trends in Neurology
Volume 5 

Copyright © 2011 Research Trends. All rights reserved

ABSTRACT
 
Clenbuterol is a β-2 adrenergic receptor agonist that causes some benefical and some undesirable effects. These can be associated to clenbuterol’s ability to increase protein synthesis as well as apoptosis by adenylyl cyclase activity via interaction with GTP binding proteins. Clenbuterol has the chemical structure of an amine that has been reported to be modulator of neuronal development.  In this work, we studied the changes induced by clenbuterol on chick embryos during early nervous system development after exposure to clenbuterol chlorhydrate 1.5 μg, 3.1 μmg and 6.2 μg. The results showed the decrease in the number of normal embryos and the increase of abnormal ones; that was statistically significant for the groups treated with 3.1 μg and 6.2 μg.
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