ABSTRACT Clenbuterol is a β-2 adrenergic receptor agonist that causes some benefical and some undesirable effects. These can be associated to clenbuterol’s ability to increase protein synthesis as well as apoptosis by adenylyl cyclase activity via interaction with GTP binding proteins. Clenbuterol has the chemical structure of an amine that has been reported to be modulator of neuronal development. In this work, we studied the changes induced by clenbuterol on chick embryos during early nervous system development after exposure to clenbuterol chlorhydrate 1.5 μg, 3.1 μmg and 6.2 μg. The results showed the decrease in the number of normal embryos and the increase of abnormal ones; that was statistically significant for the groups treated with 3.1 μg and 6.2 μg.
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