Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Cell & Molecular Biology   Volumes    Volume 5 
Targeting TGFβ signaling in human cancer therapy
Laure Humbert, Jean-Charles Neel, Jean-Jacques Lebrun
Pages: 69 - 107
Number of pages: 39
Trends in Cell & Molecular Biology
Volume 5 

Copyright © 2010 Research Trends. All rights reserved

TGFβ belongs to a large family of widespread and evolutionarily conserved polypeptide growth factors that contributes to the orchestration and modulation of the developmental program, growth and differentiation profile and functional homeostasis of almost all cell types and tissues. Mutation or deletion of TGFβ signaling components is frequent in human cancer indicating a tumor suppressor role for this growth factor. However TGFβ has a dual role in cancer since TGFβ growth inhibitory responses in early stage cancer are replaced by invasive and pro-metastatic responses in advanced stages. These autocrine and paracrine pro-metastatic effects gave rise to the development of novel anti-cancer therapies. Several strategies have been developed to counteract the pro-metastatic activities of TGFβ: blocking the generation of TGFβ, blocking the interaction of TGFβ with its cognate receptors, and blocking the signaling cascade following receptor activation. These different approaches have yielded promising results and several molecules are currently in advanced clinical trials. Finally a novel class of small non-coding RNAs, the micro-RNAs, may represent interesting targets. Indeed, microRNAs are key regulators of biological processes and are involved in the development and progression of human diseases, particularly cancer. Thus, microRNA-based therapies could potentially modulate the pro-metastatic arm of TGFβ signaling specifically without affecting the tumor suppressor arm. In this review, we will describe the various existing strategies aiming at targeting TGFβ signaling in human cancer as well as potential novel approaches targeting microRNAs.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms