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Current Trends in Medicinal Chemistry   Volumes    Volume 5 
Abstract
Synthesis of bio-active compounds from cyclitol derivatives provided by bioconversion of myo-inositol
Seiichiro Ogawa, Miki Kanto
Pages: 1 - 13
Number of pages: 13
Current Trends in Medicinal Chemistry
Volume 5 

Copyright © 2008 Research Trends. All rights reserved

ABSTRACT
 
Biogenesis of myo-inositol has been shown to readily produce adequate amounts of optically active deoxyinositols, (+)-epi- and (–)-vibo-quercitols, which can be applied as versatile synthetic intermediates for development of new cyclitol derivatives of biological interest. In this review we describe new preparation of 1,3,4-trisphosphates of 3- and 6-deoxy-myo-inoisitols, several 1,2- and 2,3-anhydro-6-deoxyinositols, including potent glycosidase inhibitors, and biologically active deoxyinosamines. The synthetic approach adopted provides a basis for further design and synthesis of bioactive cyclitol derivatives.
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