Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Comparative Biochemistry & Physiology   Volumes    Volume 5 
The peroxisomal thiolase (3- oxoacyl-CoA thiolase). Its structure and function
Vijay Kumar Dasari, Valérie Nicolas-Frances, Norbert Latruffe
Pages: 297 - 300
Number of pages: 4
Trends in Comparative Biochemistry & Physiology
Volume 5 

Copyright © 1998 Research Trends. All rights reserved

The peroxisomal 3-oxoacyl-CoA thiolase (thiolase) is the enzyme involved in the last step of β- oxidation of fatty acids to acyl-CoA and acetyl-CoA. The enzyme is nuclear encoded, synthesized in the cytoplasm and imported into peroxisomes. The importance of studying thiolase is that it generates acetyl-CoA which is a precursor for the synthesis of molecules like cholesterol and other fatty acids. The structural and functional analysis of thiolase at the molecular level may add to the knowledge of fatty acid metabolism. It is known that several genes mediate lipid homeostasis in target organs like liver and adipose tissue and are regulated by peroxisome proliferator-activated receptor (PPAR). This review will focus on the structural and functional aspects of thiolase, its isoforms, and their comparison at the molecular level.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms