Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Pharmacology   Volumes    Volume 6 
Aging and NMDA receptor
Beatriz Martínez-Villayandre, Arsenio Fernández-López, Miguel A. Chinchetru, Pedro Calvo-Fernández
Pages: 191 - 195
Number of pages: 5
Current Topics in Pharmacology
Volume 6 

Copyright © 2002 Research Trends. All rights reserved


The age-related declines of cognition and memory are well known in humans and other animals; and the N-Methyl-D-Aspartate (NMDA) receptor, a subtype of Glu receptors, is believed to be involved not only in neuronal transmission, memory and learning processes but also in pathological processes of neuronal loss by excitotoxic injury following ischemia and hypoglycemia and in the early stages of pathophysiology of senile dementia of Alzheimer`s type. Due to this functional significance of the NMDA receptor, a decline might underlie age-related deficits in learning and memory. Indeed in the aged rodent brain declining of NMDA receptors have been reported in the cerebral cortex and hippocampal regions, although there are some conflicting results concerning their levels in the hippocampus. Because of all this, we have also examined the influence of age on NMDA receptor using a quantitative in vitro autoradiographic technique.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms