Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Trends in Photochemistry & Photobiology   Volumes    Volume 6 
Neutrophil-associated events in the inflammation of cancerous tissue following treatment with photodynamic therapy
Ivana Cecic, Mladen Korbelik
Pages: 53 - 61
Number of pages: 9
Trends in Photochemistry & Photobiology
Volume 6 

Copyright © 1999 Research Trends. All rights reserved


Photodynamic Therapy (PDT) has been employed as a treatment for the eradication of solid tumors. This treatment involves the administration of a photosensitive drug, excited by light of appropriate wavelength, causing localized tumor cell death in the presence of oxygen. A marked feature of PDT-induced cell death is a strong, acute inflammatory host response. Parallel to other inflammatory reactions, the immune response induced by PDT is characterized by edema formation, and the infiltration of inflammatory cells. The first inflammatory cell type to arrive at a site of cell damage is the neutrophil. Accumulating evidence indicates that activated neutrophils sequester in tumors during and following PDT light treatment, and their engagement gives an indispensable contribution to the success of this anti-tumor modality. This review therefore summarizes the role of neutrophils in inflammation and shows how the activity of these cells contributes to the effective eradication of solid tumors by PDT.

Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms