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Current Topics in Steroid Research   Volumes    Volume 6 
Abstract
Synthesis of novel hybrid steroids with potential biological activities: Synthesis of C-17-thiazole, isoxazole, pyrazole, thiophene and phthalazine derivatives of epi-androsterone
Rafat M. Mohareb, Senot H. Doss, Gamal A. Elmegeed, Emad F. Eskander
Pages: 49 - 61
Number of pages: 13
Current Topics in Steroid Research
Volume 6 

Copyright © 2009 Research Trends. All rights reserved

ABSTRACT
 
In the aim of identifying new steroidal agents with potential biological activities, we synthesized hybrid steroids containing thiazole, pyrazole, isoxazole, thiophene or phthalazine moiety. Epi-androsterone 1 reacted with phenylthiosemicarbazide to afford the corresponding phenylthiosemicarbazonoandrostane derivative 2. The latter product was used in synthesis of a series of annulated steroid derivatives. Also, epi-androsterone 1 reacted with the thienopyridazine derivative 16 to afford the thieno[3,4-d]pyridazino-N-ylidenoandrostane derivative 17. Compound 17 reacted readily with electron poor olefins to yield the corresponding phthalazine steroid derivatives. Analytical and spectroscopic evidence for the structures of the newly synthesized compounds are described.
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