ABSTRACT In the aim of identifying new steroidal agents with potential biological activities, we synthesized hybrid steroids containing thiazole, pyrazole, isoxazole, thiophene or phthalazine moiety. Epi-androsterone 1 reacted with phenylthiosemicarbazide to afford the corresponding phenylthiosemicarbazonoandrostane derivative 2. The latter product was used in synthesis of a series of annulated steroid derivatives. Also, epi-androsterone 1 reacted with the thienopyridazine derivative 16 to afford the thieno[3,4-d]pyridazino-N-ylidenoandrostane derivative 17. Compound 17 reacted readily with electron poor olefins to yield the corresponding phthalazine steroid derivatives. Analytical and spectroscopic evidence for the structures of the newly synthesized compounds are described.
Buy this Article
|