ABSTRACT In our ongoing research on the active principles of Mexican medicinal Solanum species, it was found that the methanolic extracts of the leaves of S. chrysotrichum and S. hispidum exhibited potent antimicotic activity against Trichophyton mentagrophytes, T. rubrum, Aspergillus niger, and Candida albicans, while the methanolic extracts of the leaves of S. lanceolatum and S. rostratum displayed in vivo anti-inflammatory activity against TPA-induced mouse ear edema. Using bioactivity-directed isolation procedures, five spirostan saponins from Solanum chrysotrichum, and four spirostanol saponins from S. hispidum were isolated as the antimycotic principles, while purification of the anti-inflammatory extracts of S. lanceolatum and S. rostratum afforded two series of seven new pseudoglycolipid homologues named lanceolitols A1-A7 and lanceolitols B1-B7 from S. lanceolatum, and b-sitosteryl glucoside from S. rostratum as the anti-inflammatory principles. Due that Solanum chrysotrichum proved to be the most important antimycotic species, a series of pharmacological, micro-biological, clinical, and biotechnological studies have been performed in this important Mexican medicinal plant.
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