Home | My Profile | Contact Us
Research Trends Products  |   order gateway  |   author gateway  |   editor gateway  
Register | Forgot Password

Author Resources
 Author Gateway
 Article submission guidelines

Editor Resources
 Editor/Referee Gateway

 Regional Subscription Agents/Distributors
Current Topics in Toxicology   Volumes    Volume 6 
Blood changes generated after vanadium inhalation
Adriana González-Villalva, Vianey Rodriguez-Lara, Luis F. Montaño, Araceli Lima-Melo, Guadalupe Ramirez, Teresa I. Fortoul
Pages: 31 - 38
Number of pages: 8
Current Topics in Toxicology
Volume 6 

Copyright © 2009 Research Trends. All rights reserved

Reports about vanadium inhalation toxicity on the hematopoietic system are limited, reason why we decided to evaluate vanadium effects on blood counts and morphologic analysis in blood smears. Male mice inhaled V2O5 0.02M twice a week/12w. Samples were obtained by direct heart puncture; smears were used for morphologic evaluation and blood cells quantification. Hemoglobin, hematocrit, total serum proteins and fibrinogen were also evaluated. Normocytic anemia was evidenced, as well as leukocytosis, neutrophilia, lymphocytosis, thrombocytosis and megaplatelets. Fibrinogen, total serum proteins also increased. These findings suggest that inhaled vanadium induces blood modifications that suggest chronic systemic inflammation. Thrombocytosis and fibrinogen increase correlated with thromboembolic diseases that have been associated with suspended particles inhalation. Leukocytosis with neutrophilia and lymphocytosis could also participate in the chronic inflammation, possibly generated as a consequence of oxidative stress induced by vanadium. Further analysis is needed to dissect this phenomena and its implication in human health.
Buy this Article


Buy this article
Buy this volume
Subscribe to this title
Shopping Cart

Quick Links
Search Products
Browse in Alphabetical Order : Journals
Browse by Subject Classification : Journals

Ordering Information Ordering Information
Downloadable forms Downloadable Forms