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Current Trends in Medicinal Chemistry   Volumes    Volume 6 
Abstract
Minor groove binders: Some recent research in drug development
Abedawn I. Khalaf
Pages: 53 - 63
Number of pages: 11
Current Trends in Medicinal Chemistry
Volume 6 

Copyright © 2009 Research Trends. All rights reserved

ABSTRACT
 
The role of the naturally occurring polyamides distamycin and netropsin as antibacterial agents is described. Also, the importance of the modifications to the lipophilic and hydrophobic moieties is discussed. It has also been shown that these DNA minor groove binding compounds can be used to treat other diseases such as sleeping sickness when the right modifications have been employed. Examples of the synthetic strategy of these poly-pyrroles are also highlighted in this review.

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