When numerous cationic sites are incorporated into the structure of otherwise organic substances, intriguing properties might be anticipated. Indeed, quite interesting characteristics (physical, chemical and biochemical) have been observed for such substances. The present consideration is concerned with several aspects of polyammonium salts studied in this laboratory, including the syntheses of both classical polymeric and structurally defined substances, as well as several categories of characteristics associated with them. Directions for continued development of this area of chemical science are also discussed.